Cypriot freedom from the Persians finally comes in 333 BCE when Alexander the Great decisively defeats Persia at the Battle of Issus.

The Cypriot kings are granted autonomy a short time later in return for helping Alexander at the siege of Tyre.

The death of Alexander in 323 BCE signals the end of this short period of self-government.

Alexander's heirs fight over Cyprus, a rich prize, for several years, but in 294 BCE it is taken by Ptolemy, one of Alexander's generals, who has established himself as satrap (and eventual king) of Egypt.

Under the rule of the Ptolemies, which will last for two and one-half centuries, the city-kingdoms of Cyprus are abolished and a central administration established.