A method of inducing immunity to smallpox …

Years: 1720 - 1720

A method of inducing immunity to smallpox was already known in the seventeenth century, as shown in historical records.

The more hazardous variolation or inoculation—inoculation with smallpox pustules themselves—had been practiced throughout the latter half of the seventeenth century by physicians in India, China, Turkey, Persia, and Africa.

One document in particular, Essay on External Remedies (1715) by a Dr. Kennedy, who was doing research in Constantinople, had documented physicians there: "[The physician]...scarred the wrists, legs, and forehead of the patient, placed a fresh and kindly pock in each incision and bound it there for eight or ten days, after this time the patient was credibly informed. The patient would then develop a mild case [of smallpox], recover, and thereafter be immune."

This technique was documented as having a mortality rate of only one in a thousand.

Two years after Kennedy's description appeared, March 1718, Dr. Charles Maitland had successfully inoculated the five-year-old son of Edward Wortley Monagu, British ambassador to the Turkish court under orders from his wife Lady Mary, whose beauty had been marred by a severe attack of smallpox while she was still a young woman, and who four years later will introduce the practice to England.

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