The later Caddo, having given way over years before the power of the former Ohio Valley tribes, negotiate for peace with the waves of Spanish, French, and finally Anglo-American settlers.

After the 1803 Louisiana Purchase, by which the United States has taken over the former French colonial territory west of the Mississippi River, the U.S government seeks to ally with the Caddo peoples.

During the War of 1812, American generals such as William Henry Harrison, William Clark, and Andrew Jackson crush pro-British uprisings among other Southeast Indians, in particular the Creeks.

Due to the Caddo's neutrality and their importance as a source of information for the Louisiana Territory government, they are left alone.