The Panama Canal Zone (Spanish: Zona del Canal de Panamá) is a 553-square-mile (1,430 km2) former unorganized US territory located within the Republic of Panama consisting of the Panama Canal and an area generally extending five miles (8.0 km) on each side of the centerline, but excluding Panama City and Colón, which otherwise would have been partly within the limits of the Canal Zone.

Its border spans two of Panama's provinces and is created on November 18, 1903, with the signing of the Hay–Bunau-Varilla Treaty.

When reservoirs are created to assure a steady supply of water for the locks, these lakes are included within the Zone.