The Talpur dynasty (Persian: دودمان شاهی تالپور) was a Baloch dynasty that ruled the Sind State (present-day Sindh, Pakistan) after overthrowing the Kalhora dynasty in 1783 until British conquest of Sindh in 1843. A branch of the family continued to rule Khairpur, under British suzerainty and later as a Pakistani princely state, until 1955 when it was amalgamated into West Pakistan.

For most of their rule, they were subordinate to the Khanate of Kalat and subject to the Durrani Empire, being forced to pay tribute to them.