The Yaocomico, or Yaocomaco, are an Algonquian-speaking Native American group who live along the north bank of the Potomac River near its confluence with the Chesapeake Bay in the seventeenth century.

They are related to the Piscataway, the dominant nation north of the Potomac.The settlers who arrive to establish the English colony of Maryland purchase land for their first settlement from the Yaocomico.

By the late-seventeenth century, the tribe has disappeared from the historical record.

Historians believe this was mostly due to epidemics of newly introduced infectious disease and to pressure from European settlers and other Native groups.