The Siege of Cannanore (1507) is a four-month siege, from April to August 1507, when troops of the local ruler (the Kōlattiri Raja of Cannanore), supported by the Zamorin of Calicut and Arabs, besieg the Portuguese garrison at St. Angelo Fort in Cannanore, in what is now the Indian state of Kerala.

It followed the Battle of Cannanore (1506), in which the fleet of the Zamorin is defeated by the Portuguese.