The Battle of Maclodio is fought on October 11, 1427, resulting in a victory for the Venetians under Carmagnola over the Milanese under Carlo I Malatesta.

The battle is fought at Maclodio (or Macalo) a small town near the River Oglio, fifteen kilometers (nine miles) southwest of Brescia.

This battle, fought during the second campaign, is the only decisive victory for Venice in the Wars in Lombardy.

This battle forces the Milanese into a treaty, conceding Brescia in 1428, though fighting of the wars in Lombardy is to resume later, continuing until the Treaty of Lodi in 1454.