An Ottoman-Mamluk war takes place between 1485–1491, when the Ottoman Empire invades the Mamluk Sultanate territories of Anatolia and Syria.

This war is an essential event in the Ottoman struggle for the domination of the Middle East.

After multiple encounters however, the war ends in a stalemate and a peace treaty is signed in 1491, restoring the status quo ante.

It will last until the Ottomans and the Mamluks again go to war in 1516–17.