The Saint-Domingue expedition is a French military expedition sent by Napoleon Bonaparte, then First Consul, under his brother-in-law Charles Victor Emmanuel Leclerc in an attempt to regain French control of the island of Saint-Domingue and curtail the measures of independence taken by the former slave Toussaint Louverture.

It lands in December 1801 and, after initial success, and ends in a French defeat at the battle of Vertières and the departure of French troops in December 1803.