Antony’s affair with Cleopatra will result in three children, Alexander Helios, Cleopatra Selene II and Ptolemy Philadelphus.

Antony early in 40 receives two pieces of bad news: that his brother Lucius Antonius and his third wife, Fulvia, on their own initiative and without success, have revolted against Octavian, thus setting off the Perusine War (after the central point of the rising, Perusia, the modern Perugia); and that the Parthians, the eastern neighbors of Rome’s republican empire, have invaded Roman Syria.

In spite of the latter information, Antony, aware of his deteriorating relationship with Octavian, leaves Cleopatra in Egypt and first proceeds to Italy with a large force to oppose Octavian.

Herod and Antony are old friends; but after Antony's departure, Cleopatra had tried unsuccessfully to seduce Herod on his way through Egypt.

Cleopatra will never forgive him for the rebuff.

Her twins by Antony, named Cleopatra Selene and Alexander Helios, are born on December 25 of this year.