The Romano-British may have been disproportionately affected…

The Romano-British may have been disproportionately affected because of trade contacts with Gaul and other factors, such as British settlement patterns being more dispersive than English ones.

The differential effects may have been exaggerated.

However, scholars (like Lester K. Little et alii in their Plague and the End of Antiquity: The Pandemic of 541–750), as evidence that the plague damage done on the Sub-Roman Britons was greater than the one suffered by the Anglo-Saxons, believe that the sudden disappearance around 560 of the important Roman town of Calleva was probably due to the Plague of Justinian, which will later created a kind of curse on the city "damned" by the Anglo-Saxons.