Diodotus, a local Greco-Bactrian governor, declares the independence of the Afghan plain of the Amu River, in about 250 BCE.

Ptolemy reasserts his influence in the Aegean while the Macedonian forces are bogged down in Greece, making good the setback suffered during the Chremonidean War.

The Romans, shifting their attention to the southwest in 250, send a naval expedition toward Lilybaeum.

En route, the Romans seize and burn the Carthaginian holdout cities of Selinus and …

…Heraclea Minoa.

This expedition to Lilybaeum is not successful, but attacking the Carthaginian headquarters demonstrates Roman resolve to take all of Sicily.

Halley's comet, which swings around the Sun once every seventy-six years, becomes known to astronomers in 240 BCE.

Its orbital period over the last three centuries has been between seventy-five and seventy-six years, though it has varied between seventy-four and seventy-nine years since its discovery.

The Qin state, centered in present Shaanxi (Shenxi), has emerged as the most powerful of the Warring Kingdoms.

The once-mighty Seleucid kingdom had in the beginning of the third century BCE begun to lose control over large territories.

Parthia, Bactria, and Sogdiana have by the middle of this century gained their independence.

The Middle East: 249–238 BCE

Parthian Emergence and Hellenistic Decline

Rise of Arsaces and the Parthian State

In 247 BCE, following the death of Antiochus II, Seleucid control weakens as their governor (satrap) of Parthia, Andragoras, declares independence amidst the turmoil caused by the seizure of the Seleucid capital Antioch by Ptolemy III. Andragoras struggles to defend his territory without Seleucid military backing.

Around 238 BCE, the situation deteriorates further when Arsaces, a leader of the nomadic Parni tribes of Scythian or Bactrian origin, launches a decisive invasion into Parthia, aided by his brother Tiridates. Quickly capturing Astabene (Astawa) and its capital, Kabuchan (modern Kuchan), the Parni decisively end Andragoras' rule, killing him in the process. The Parni tribes subsequently adopt the name Parthians, derived from the conquered province, marking the birth of a new and influential Persian dynasty.

Advances in Hellenistic Astronomy

Amidst these geopolitical shifts, significant advancements occur in Greek astronomy. Aristarchus of Samos, a prominent student of Strato of Lampsacus, advocates for a revolutionary heliocentric model, asserting that the Sun, not the Earth, is the center of the universe. Aristarchus also conducts pioneering work in determining celestial distances. In his surviving treatise, On the Sizes and Distances of the Sun and Moon, he uses geometric reasoning to calculate that the Sun is approximately twenty times further away and twenty times larger than the Moon. Although his estimates are imprecise due to technological limitations, Aristarchus's methods remain conceptually sound and significantly influence future astronomical thought.

The Third Syrian War, also known as the Laodicean War or War of Berenice, begins with one of the many succession crises that plagues the Hellenistic states.

Antiochus II leaves two ambitious mothers, his repudiated wife Laodice and Berenice Syra, the daughter of Egypt's Ptolemy II, in a competition to put their respective sons on the throne.

Laodice claims that Antiochus had named her son heir while on his deathbed, but Berenice argues that her newly born son is the legitimate heir.

Berenice asks her brother Ptolemy III, the new Ptolemaic king, to come to Antioch and help place her son on the throne.

When Ptolemy arrives, Berenice and her child have been assassinated.

Ptolemy declares war on Laodice's newly crowned son, Seleucus II, in 246 BCE, and campaigns with great success.

He wins major victories over Seleucus in Syria and Anatolia, briefly occupies Antioch and, as a recent cuneiform discovery proves, even reaches Babylon.

These victories are marred by the loss of the Cyclades to Antigonus Gonatas in the Battle of Andros.

Seleucus has his own difficulties.

His domineering mother asks him to grant co-regency to his younger brother, Antiochus Hierax, as well as rule over Seleucid territories in Anatolia.

Antiochus promptly declares independence, undermining Seleucus' efforts to defend against Ptolemy.

Ptolemy, in exchange for a peace in 241 BCE, is awarded new territories on the northern coast of Syria, including Seleucia Pieria, the port of Antioch.

The Ptolemaic kingdom is at the height of its power.

Andragoras, the Seleucid governor (satrap) of Parthia (roughly, western Khorasan) had proclaimed independence from the Seleucids in 247 BCE, when—following the death of Antiochus II—Ptolemy III had seized control of the Seleucid capital at Antioch.

Meanwhile, one Arsaces, of Scythian or Bactrian origin, has been elected leader of the Parni tribes.

Following the secession of Parthia from the Seleucid Empire and the resultant loss of Seleucid military support, Andragoras has difficulty in maintaining his borders, and about 238 BCE—under the command of Arsaces and his brother Tiridates—the Parni invade Parthia and seize control of Astabene (Astawa), the northern region of that territory, the administrative capital of which is Kabuchan (Kuchan in the vulgate).

The Parni shortly seize the rest of Parthia from Andragoras, killing him in the process, and soon become known as the Parthians, taking their name from the Seleucid province that they have conquered.