The southern Tuscarora collaborate with the Pamlico,…

The southern Tuscarora collaborate with the Pamlico, the Cothechney, the Coree, the Mattamuskeet and the Matchepungoe nations to attack the settlers in a wide range of locations within a short time period.

Their principal targets are against the planters on the Roanoke, Neuse and Trent rivers, as well as the city of Bath.

They attack on September 22, 1711, beginning the Tuscarora War.

The disputed government during the period from 1708 to 1711 had severely weakened the position of the colonists in North Carolina.

The chaos and dissension that the Cary Rebellion has wrought impedes the colonial response, though a drought and yellow fever epidemic also play a role.

The Cary rebellion also represents the end of the role of Quakers in North Carolina governance.

After the rebellion, they are effectively excluded from politics.