Thutmose I organizes great building projects, including many temples and tombs, but his greatest projects ae at the Temple of Karnak under the supervision of the architect Ineni.

Previous to Thutmose, Karnak probably consisted only of a long road to a central platform, with a number of shrines for the solar bark along the side of the road.

Thutmose is the first king to drastically enlarge the temple.

Thutmose has the fifth pylon built along the temple's main road, along with a wall to run around the inner sanctuary and two flagpoles to flank the gateway.

Outside of this, he builds a fourth pylon and another enclosure wall.

Between pylons four and five, he has a hypostyle hall constructed, with columns made of cedar wood.

This type of structure is common in ancient Egyptian temples, and supposedly represents a papyrus marsh, an Egyptian symbol of creation.

Along the edge of this room he builts colossal statues, each one alternating wearing the crown of Upper Egypt and the crown of Lower Egypt.

Finally, outside of the fourth pylon, he erects four more flagpoles and two obelisks, although one of them (which today has fallen,) will not be inscribed until Thutmose III does so about fifty years later.

The cedar columns in Thutmose I's hypostyle hall will be replaced with stone columns by Thutmose III, however at least the northernmost two are replaced by Thutmose I himself.

Hatshepsut will also erect two of her own obelisks inside of Thutmose I's hypostyle hall.