Epidemics of smallpox and cholera, and endemic…
1859 CE
From an estimated population of twelve thousand in the 1830s, they are reduced to thirty-four hundred by 1859.
Residing in what will become Nebraska territory, the Pawnee had been relatively isolated from interaction with Europeans until the 1830s.
As a result, they had not been not exposed to Eurasian infectious diseases, such as measles, smallpox, and cholera, to which Native Americans had no immunity.
In the nineteenth century, however, they are pressed by Siouan groups encroaching from the east, who also bring diseases.
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Northern North America
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