The Mixe is an indigenous group inhabiting the eastern highlands of the Mexican state of Oaxaca.
They speak the Mixe languages which is classified in the Mixe–Zoque family, and are more culturally conservative than other indigenous groups of the region, maintaining their language to this day.
A population figure of ninety housand speakers of Mixe is estimated by SIL international in 1993.
The Mixe name for themselves is ayuujkjä'äy meaning "people who speak the mountain language" The word "Mixe" itself is probably derived from the Nahuatl word for cloud: mīxtli.