Alexios Philes is a Byzantine nobleman and general of the thirteenth century.
He is the son of Theodore Philes, governor of Thessalonica and the first prominent member of the Philes family.
Alexios marries Maria Palaiologina Kantakouzene, the second daughter of John Kantakouzenos and Irene-Eulogia, the sister of Emperor Michael VIII Palaiologos (r. 1259–1282).
In 1259, the Byzantine emperor appoints Philes as megas domestikos (commander-in-chief of the army) in succession to Alexios Strategopoulos, who had been promoted to Caesar after his victories against the Despotate of Epirus.
In 1262/1263, Philes is dispatched along with the parakoimomenos John Makrenos to the Morea, in an expedition against the Principality of Achaea headed by the sebastokrator Constantine Palaiologos.
The Byzantine forces are defeated at the Battle of Prinitza, and after the sebastokrator departs for Constantinople, Philes and Makrenos are left in charge.
They too, however, are defeated and captured by the Achaeans at the Battle of Makryplagi.