Sebastião's death causes the crown to fall to his uncle, Henrique, the last surviving son of Manuel I.

Henrique's crowning solves the succession crisis only temporarily because Henrique is an infirm and aged cardinal who is unable to obtain dispensation from the pope to marry.

There are several pretenders to the throne, one of whom is Philip II of Spain, nephew of Joao III.

When Henrique dies in 1580, a powerful Spanish army commanded by the duke of Alba invades Portugal and marches on Lisbon.

This force routs the army of rival contender, Antonio, prior of Crato and the illegitimate son of Joao Ill's son Luis.

Portugal is annexed by Spain, and Philip II is declared Filipe I of Portugal.