This outbreak of plague also spreads north into Tyrol, an alpine region of western Austria and northern Italy.

German and French troops carry the bubonic plague to the city of Mantua in 1629, as a result of troop movements associated with the Thirty Years' War (1618–1648).

Venetian troops, infected with the disease, retreat into northern and central Italy, spreading the infection.

Milan, Lombardy's major commercial center, is devastated by the plague introduced by the armies in the winter of 1629-30, an event that will be vividly described in Alessandro Manzoni's 1840 novel The Betrothed (Italian: I promessi sposi).

Milan loses forty-six percent of its pre-plague population of one hundred and thirty thousand.

East of Lombardy, the Republic of Venice is infected in 1630–31.

The city of Venice is severely hit, with recorded casualties of thirty-three percent: forty-six thousand out of a population of one hundred and forty thousand.

Some historians believe the drastic loss of life, and its impact on commerce, ultimately resulted in the downfall of Venice as a major commercial and political power.

The papal city of Bologna loses an estimated fifteen thousand citizens to the plague, representing twenty-four percent of its inhabitants, with ...

...neighboring smaller cities of Modena and ...

...Parma also being heavily affected.

Verona has the highest mortality rate, losing sixty-one percent of its population of fifty-four thousand; ...

...the city of Florence loses nine thousand, or twelve percent, of its seventy-six thousand citizens.

Later outbreaks of bubonic plague in Italy will include Florence in 1630–1633 and the areas surrounding Naples, Rome and Genoa in 1656–57.