The Ile Saint-Jean Campaign is a series of military operations in fall 1758, during the Seven Years' War, to deport the Acadians who either live on Ile Saint-Jean (present-day Prince Edward Island) or have taken refuge there from earlier deportation operations.
Lieutenant-Colonel Andrew Rollo leads a force of five hundred British troops (including James Rogers leading his company of Rogers Rangers) to take possession of Ile Saint-Jean.
The percentage of deported Acadians who die during this expulsion makes it the deadliest of all the deportations during the Expulsion (1755–1762).
The total number of Acadians deported during this campaign is second only to that of the Bay of Fundy Campaign (1755).