The death toll from the epidemic is…
1593 CE
A number of small villages or hamlets lose most of their populations during the epidemic, and are later abandoned or absorbed into nearby settlements.
During the plague of 1592–93, the deceased are not buried in churches but in extra-mural plague cemeteries which are specially set up to deal with the epidemic
This is the first recorded instance that such cemeteries are established in Malta, and similar ones will be set up in later major outbreaks of the disease, such as in 1675–76 and 1813–14.