The Italian city-states gradually lose their independence…
1540 CE to 1683 CE
In 1629–1631, a new outburst of plague claims about fourteen percent of Italy's population.
In addition, as the Spanish Empire starts to decline in the seventeenth century, so do its possessions in Naples, Sicily, Sardinia, and Milan.
In particular, Southern Italy is impoverished and cut off from the mainstream of events in Europe.