The philosopher Francisco Sanches in 1581 writes…

The philosopher Francisco Sanches in 1581 writes a famous skeptical tract, In Quod Nihil Scitur (“Why Nothing Can Be Known”), in which he explains that true knowledge is impossible because sense faculties are unreliable and cannot reach the true nature of things; that, moreover, the world is in constant flux and (because all things are related) no one thing can be understood without understanding all other things, their causes, the causes of their causes, and so forth; and that reliable knowledge is exhaustive and belongs to God alone.

The “constructive skepticism” espoused by Sanchez rejects mathematical truths as unreal and Aristotle's theory of knowledge as false.

Sanchez had in 1574 received a medical degree at Montpellier and teaches philosophy at the University of Toulouse.