The Spanish force—who are also suffering serious…

The Spanish force—who are also suffering serious losses from fever—close in on Fort St. Andrew and besiege it for a month, although disease is still the main cause of death during this time.

The Spanish commander calls for the Scots to surrender and avoid a final assault, warning that if they do not no quarter will be given.

After negotiations, the Scots are allowed to leave with their guns, and the colony is abandoned for the last time.

Only a handful of those from the second expedition return to Scotland.