The spice trade no longer goes through…
1492 CE to 1503 CE
The spice trade no longer goes through the Mediterranean Sea after the great Portuguese explorations that open up new ocean routes.
Moreover, the discovery of America has started a crisis of Mediterranean shipping.
This is the beginning of the decline of both the Venetian and Ragusan Republics.
Charles VIII of France had granted trading rights to the Ragusans in 1497.
These rights are also granted by Louis XII in 1502.