Francis Willoughby, 5th Baron Willoughby of Parham (baptised 1614 – July 123, 1666 O.S.) is an English peer of the House of Lords.
He succeeds to the title on October 14, 1617, on the death in infancy of his elder brother Henry Willoughby, 4th Lord Willoughby of Parham.
Francis Willoughby is the second son of William Willoughby, 3rd Lord Willoughby of Parham.
The young and unexpected death of his elder brother Henry made Francis successor to the hereditary peerage and seat in the House of Lords, the upper house of Parliament.
Francis Willoughby is an early supporter of the Parliamentarian cause during the English Civil War but later becomes a Royalist.
He twice serves as governor of English colonies in the Caribbean.
Francis Willoughby dies without male heirs of his body and the title passes to his younger brother William Willoughby, 6th Lord Willoughby of Parham.