Person

Giacomo Pylarini

Venetian physician and consul

b. 1659 CE – d. 1718 CE World The Great Crossroads

Giacomo Pylarini (Jacob) (born 1659 – 1718) was a Venetian physician and consul for the republic of Venice in Smyrna who in 1701 on the children of the English ambassador to Constantinople, gave the first smallpox inoculation outside of Turkey.

This early immunization effort is called "variolation".

Moran, J. (2017). Giacomo Pylarini. History Atlas. Retrieved 12 October 2026, from https://www.historyatlas.com/people/giacomo-pylarini/

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