The Reverend James Cantine, D.D. (March 3, 1861 – July 1, 1940) is an American missionary, scholar, and traveler.
While studying at New Brunswick Theological Seminary in New Jersey, he co-founds the Arabian Mission with John Lansing and Samuel Marinus Zwemer.
The mission exists today as the American Mission Hospital of Bahrain.
He is a missionary for forty years, which includes establishing the first mission for the Reformed Church in Arabia, which is also the first mission in eastern Arabia.
Between 1891 and 1929, he establishes mission posts, medical clinics, and churches in Arabia.
His wife, Elizabeth, is a nurse and the first single woman to become a missionary in Arabia.
Together they found a women's clinic in Muscat, Oman, work at missionary posts, and when the United Missions is formed, they are both representatives of the Reformed Church in America for the organization.
Cantine co-authors the book, The Golden Milestone: Reminiscences of Pioneer Days Fifty Years in Arabia with Zwemer.