Count Karl Robert Nesselrode, also known as Charles de Nesselrode, (Lisbon, Portugal,  December 14, 1780 – Saint Petersburg, March 23, 1862) is a Russian Empire diplomat of Baltic-German descent.

His mother is Jewish by origin and Protestant by faith.

For forty years (1816-1856) Nesselrode as foreign minister guides Russian policy; he is a leading European conservative statesman of the Holy Alliance.