Manisa becomes in 1313 a permanent Turkish possession when taken by the Beylik of Saruhan, led by the Bey of the same name who had started out as a tributary of the Seljuks and who reigns until 1346.
His sons hold the region until 1390, when the first incorporation of their lands into the expanding Ottoman state takes place.
After a brief interval caused by the Ottoman interregnum after the Battle of Ankara, Manisa and its surroundings definitely become part of the Ottoman Empire in 1410.
