María Alfonso Téllez de Menezes (c. 1265 – 1321), known as María de Molina, is the wife of Sancho IV of Castile.
She is queen consort of Castile and León from 1284 to 1295, and serves as regent for her minor son Ferdinand IV(1295 - c.1301) and later her grandson Alfonso XI of Castile (1312-1321).