Mohammad Afzal Khan (1811 – October 7, 1867) is the Emir of Afghanistan from 1865 to 1867.The oldest son of Dost Mohammed Khan, Afzal Khan seizes power from his brother Sher Ali Khan three years after their father's death.
Following Afzal Khan's death the following year, Mohammad Azam Khan is reinstated as Amir of Afghanistan.
He is an ethnic Pashtun and belongs to the Barakzai tribe.