Isatai'i (Comanche isa 'wolf or coyote' + tai'i 'vagina') or Isatai (c.1840 – 1916) is a Comanche warrior and medicine man of the Kwaharʉ band.
Originally named Kwihnai Tosabitʉ (White Eagle), after the debacle at Adobe Walls on June 27, 1874, for which he is blamed, he is known as Isatai'i.
Isatai'i gains enormous prominence for a brief period in 1873-74 as a prophet and "messiah" of Native Americans.
He succeeds, albeit very temporarily, in uniting the autonomous Comanche bands as no previous Chief or leader has ever done.
Indeed, his prestige is such that he is able to organize what is said to be the first Comanche sun dance, an Indian ritual that his tribe has not previously adopted.