Tens of thousands of South American natives …

Years: 1396 - 1539
Tens of thousands of South American natives succumb to smallpox, measles, tuberculosis, typhoid, dysentery, and influenza.

Whole peoples are likely annihilated without having had direct contact with Europeans, as disease is carried along the indigenous trade routes.

The early European chroniclers of South America write of multitudes along the coast and of dense populations in the Amazon Basin.

Far from being awed by the newcomers, the indigenous inhabitants display curiosity and hospitality, a willingness to exchange goods, and a distinct ability at aggressive defense.

However, they cannot prevent the devastation caused by the diseases carried by the Europeans and Africans.

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